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M1: Anticholinergics
scopolamine (Transderm Scop) 1.5mg q72 hrs SE: dry mouth, dizzy, vision disturbance |
H1: Antihistamines
diphenhydramine (Benadryl) 25-50mg po q6hrs; 10-50 IM/IV dimenhydrinate (Dramamine) 50mg po q4hrs cyclizine (Marezine) 50 mg po/IM q4hrs; 100mg pr q4hrs meclizine (Antivert) 25-50mg po q24hrs promethazine (Phenergan) 12.5-25 mg po/IM q4hrs; 12.5-25 pr q12hrs SE: sedation |
D2: DA receptor antagonists
phenothiazines: prochlorperazine (Compazine) 5-10 mg po q6-8hrs; 5-10 IM or 2.5 IV q3-4 hrs; 25mg pr q12 hrs chlorpromazine (Thorazine) 10-25 mg po q4-6 hrs;25 IV q3-4 hrs; 100 pr q6-8hrs thiethylperazine (Torecan) 10 mg po or 2 IM q8-24hrs SE: dystonia, hypotension Butyrophenones droperidol (Inapsine) 0.625-2.5 mg IM haloperidol (Haldol) long half life 18 hrs Benzamides metoclopramide (Reglan) 10 mg po/IM/IV qid trimethobenzamide (Tigan) 250 mg po q6-8hrs; 200 mg IM |
5HT3: serotonin receptor antagonists
ondansetron (Zofran) 8 mg po/IV q12 hrs; granisetron (Granisol) 2 mg po qd; 10 mcg/kg IV dolasetron (Anzemet) 12.5 mg IV palonosetron (Aloxi) 0.075 mg IV SE: EKG changes, constipation, dizzy OTHER: Glucocorticoids dexamethasone with 5HT3 antag is choice in CTX nausea |
NK1: neurokinin antagonists
aprepitant (Emend) fosaprepitant (Emend) |